Selank Injection

Disclaimer: The following product is intended solely for research purposes. We do not promote or encourage any consumption outside of authorised trials.
What is Selank Injection?
The Selank liquid for injection administration is a synthetic heptapeptide developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. It is a synthetic analogue of tuftsin, a natural peptide that plays a vital role in immune system regulation. Designed to deliver anxiolytic and nootropic benefits, Selank Injection offers a unique approach to managing anxiety and cognitive function with a strong safety profile demonstrated in preclinical studies.
Unlike the nasal spray form, Selank injection is administered via intramuscular or subcutaneous routes (directly into muscle or into the fatty tissue layer before reaching muscle), allowing for precise dosing and rapid absorption. It is widely used in research settings to explore its effects on brain function, immune modulation, and stress response.
How Does Selank Injection Work?
Selank Injection works in several ways within the central nervous system and the immune system.

Monoamine neurotransmitter balance: Serotonin, dopamine, and norepinephrine levels play a key role in mood and anxiety. Selank helps to stabilise these chemicals in the brain.
Effect on the GABA system: Selank does not attach to GABA receptors. Instead, it changes gene activity tied to GABA, which improves calming signals in the brain.
Boost in BDNF levels: In the hippocampus, Selank boosts brain-derived neurotrophic factor (BDNF). This supports memory, learning, and brain adaptability.
Preservation of enkephalins: Enzymes that break down enkephalins, which are opioids the body produces to ease pain and stress, are blocked by Selank.
Immune system regulation: Selank works like a tuftsin analogue, adjusting the activity of immune cells and cytokine levels. This helps boost the body’s immune response.
Gene expression modulation: Selank has an effect on genes linked to making neurotransmitters, managing immune health, and dealing with stress. This shows its wide-ranging role in regulation.
Boost in BDNF levels: In the hippocampus, Selank boosts brain-derived neurotrophic factor (BDNF). This supports memory, learning, and brain adaptability.

Potential Benefits of Selank Injection
Research and clinical trials have highlighted several promising benefits:

Anxiety relief: Selank injection reduces anxiety symptoms without the sedation or dependency risks typical of many anxiolytics.
Cognitive enhancement: Studies show improved memory, attention, and learning capabilities in animal models.
Immune support: It normalises cytokine profiles and boosts immune function, especially in immunocompromised models.
Stress: In clinical trials, Selank has been recorded helping to regulate cortisol levels and preventing stress-induced immune suppression.
Neuroprotection: Studies have shown that Selank can protect neurons against oxidative stress and excitotoxicity. This is particularly important as a way to potentially reduce damage after ischemic events.
Mood stabilisation: Clinical data indicate improvements in emotional stability and mood regulation.

Safety and Usage Notes
Selank injection has been studied extensively in preclinical and clinical settings, showing a favourable safety profile:

Minimal side effects: Mild and transient effects such as headaches or injection site irritation have been reported.
No dependency: Unlike traditional anxiolytics, such as beta-blockers and diazepam, Selank does not cause physical dependence or withdrawal symptoms.
Individual response varies: Effects may differ based on personal physiology and concurrent medications.
Potential interactions: Caution is advised when combining with other neuroactive substances affecting monoamine or GABA systems, such as selective serotonin reuptake inhibitors (SSRIs), benzodiazepines, monoamine oxidase inhibitors (MAOIs), and certain antidepressants or anxiolytics. It is always advised to speak to a medical professional when taking multiple medications or peptides together.

Comprehensive long-term safety studies are still underway to provide more data on the effects of prolonged use. 
Selank Injection Data Sheet

CAS Number: 129954-34-3  
Molecular Weight: 751.9 g/mol  
Chemical Formula: C₃₃H₅₇N₁₁O₉  
Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro  
PubChem CID: 11765600
ChemSpider: 9940290
ChEMBL: CHEMBL4297607

Why Choose Selank Injection for Research?
Selank Injection is a versatile research peptide that offers a window into the complex interplay between anxiety, cognition, and immune function. Its multi-targeted action and minimal side effects make it a valuable tool for advancing neuropharmacological and immunological studies.
Sources
Selank, a Peptide Analogue of Tuftsin, Attenuates Aversive Signs of Morphine Withdrawal in Rats – PubMed
The Influence of Selank on the Level of Cytokines Under the Conditions of “Social” Stress – PubMed
Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating BDNF Content in the Hippocampus and Prefrontal Cortex in Rats – PubMed
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission – PubMed
Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats – PubMed
The temporary dynamics of inflammation-related gene expression under tuftsin aanalogueSelank action – PubMed
Naloxone-blocked depriming effect of anxiolytic selank on apomorphine-induced behavioural manifestations of hyperfunction of dopamine system – PubMed
[Changes in expression of the genes for chemokines, cytokines, and their receptors in response to selank and its fragments] – PubMed
Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission – PubMed
Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats – PubMed
Opimization of the treatment of anxiety disorders with selank] – PubMed
[Immunomodulatory effects of selank in patients with anxiety-asthenic disorders] – PubMed
Antiviral properties of structural fragments of the peptide Selank – PubMed
[Efficacy and possible mechanisms of action of a new peptide anxiolytic selank in the therapy of generalised anxiety disorders and neurasthenia] – PubMed
GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells – PubMed

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Related compounds: Selank Nasal Spray · Semax Nasal Spray · DSIP (Delta Sleep-Inducing Peptide)

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