TB500

Disclaimer: The following product is intended solely for research purposes. We do not promote or encourage any consumption outside of authorised trials.
Contents:

1x TB500 5 mg Vial
1x Bacteriostatic Water for Injection (with Benzyl Alcohol)

Overview
TB500 is a synthetic peptide derived from the naturally occurring protein Thymosin Beta-4, which plays a critical role in cellular repair and regeneration. Engineered for stability and efficiency, TB500 contains the active region of Thymosin Beta-4, allowing it to replicate its biological activity while offering advantages in shelf life, ease of use, and research viability.
Each vial contains 5 mg of TB500 in lyophilized powder form, suitable for reconstitution under sterile laboratory conditions. This compound is intended strictly for laboratory research and is not for human or veterinary use.

Scientific Background
Thymosin Beta-4 is found in virtually all human and animal cells and is particularly concentrated in sites of tissue injury. Its role in wound healing, inflammation reduction, and angiogenesis (formation of new blood vessels) has made it a focus of biomedical research.
TB500 is a smaller, synthetically optimized fragment of this larger peptide. By isolating the part of the molecule responsible for actin regulation, TB500 provides a more targeted and manageable compound for laboratory study. Its mechanisms of action are believed to center on enhanced cellular migration, modulation of inflammatory response, and stimulation of tissue regeneration.

Mechanism of Action
TB500 primarily works by promoting the polymerization of actin, a protein crucial to the cytoskeleton of all cells. By regulating actin activity, TB500 assists in cell movement and structural repair. This actin-binding property makes TB500 particularly relevant in models of wound healing and organ regeneration.
Other observed mechanisms in animal and in vitro models include:

Enhanced migration of stem cells and repair cells to damaged tissues
Stimulation of angiogenesis, improving the blood supply in injured areas
Downregulation of inflammatory cytokines, contributing to faster recovery
Support for nerve and muscle cell regeneration in various tissue types

TB500 has also demonstrated potential in models of ocular damage, cardiovascular repair, and soft-tissue injuries, making it a peptide of growing interest across multiple fields of study.

Research Applications
While not approved for medical use, TB500 has been widely explored in preclinical research for its role in healing and regeneration. Below are some of the most common applications observed in laboratory settings:
Musculoskeletal Repair
In animal studies, TB500 has been shown to accelerate the recovery of skeletal muscle, tendons, and ligaments following injury. Its ability to stimulate satellite cell activation and reduce fibrotic tissue buildup has made it an appealing peptide for orthopedic and sports-related injury research.
Cardiovascular Regeneration
TB500 is being evaluated in cardiac models for its angiogenic and anti-fibrotic properties. By increasing vascular endothelial growth factor (VEGF) expression and promoting new blood vessel formation, it may support healing in post-myocardial infarction environments.
Wound Healing and Skin Recovery
One of the earliest uses of TB500 in research involved dermal wound healing. Studies have noted accelerated epithelialization and collagen deposition in skin injury models, even under diabetic or ischemic conditions.
Joint and Tendon Health
In arthritis models, TB500 has been found to reduce swelling, improve flexibility, and slow the progression of inflammatory degradation. It’s also being tested in equine models for tendonitis and ligament damage with promising results.
Nervous System Repair
Emerging studies have indicated potential neuroregenerative effects. TB500 may support axonal regrowth and remyelination, suggesting further study in spinal cord injury or peripheral nerve damage models could be warranted.

Product Details

Compound: TB500 (Thymosin Beta-4 fragment)
Molecular Formula: C₂₁₂H₃₅₀N₅₆O₇₈S
Molecular Weight: ~4963.5 g/mol
Unit Size: 5 mg
Appearance: White lyophilized powder
Purity: ≥99% (HPLC verified)
Packaging: Sterile, light-resistant ml vial
Storage (unreconstituted): Store at -20°C
Storage (reconstituted): Refrigerate at 2–8°C and use within 20 days
Solubility: Soluble in bacteriostatic or sterile water

Verified Chemical Identifiers for TB‑500

CAS Number: 885340‑08‑9
PubChem CID: 62707662
UNII: QHK6Z47GTG

Handling & Reconstitution
TB500 is provided in lyophilized form and must be reconstituted prior to research use. It is recommended to use bacteriostatic water for injection to maintain sterility. Gently swirl the vial until fully dissolved—do not shake vigorously.
Always use aseptic techniques and proper laboratory safety protocols when handling peptides.

Lab Use Only: Not for Human Consumption
This compound is offered strictly for laboratory research use only. It is not intended for use in humans, animals, or any type of therapeutic or diagnostic application. Any improper use is strictly prohibited. By purchasing, you confirm that you are qualified to handle this compound in accordance with relevant research guidelines and safety standards.

Comparison: TB500 vs Full-Length Thymosin Beta-4

Feature
TB500
Thymosin Beta-4

Molecular Size
17 amino acids
43 amino acids

Research Stability
High
Moderate

Focused Action
Yes (targeted actin segment)
Broader biological activity

Cost Efficiency
More affordable per dose
Higher cost per unit

Common in Research Models
Yes
Less common due to instability

TB500 is favoured in research environments for its ease of storage, dosing flexibility, and reliable performance under varied conditions.

Storage Guidelines

Keep unreconstituted vials in a dark, frozen environment (-20°C) to ensure stability.
After reconstitution, store the solution in the refrigerator (2–8°C).
Avoid repeated freeze-thaw cycles to prevent degradation.
Use within 20 days after mixing for best results.

Purity & Quality Assurance
Our TB500 is manufactured in GMP-compliant laboratories and independently third-party tested. Each batch is supplied with a full Certificate of Analysis, verifying:

Amino acid sequence
Peptide mass (MS)
Purity (HPLC)
Solubility
pH and sterility

We are committed to providing researchers with consistent, reliable compounds supported by transparent documentation and professional support.

Frequently Asked Questions
Q: Is this product legal?
A: TB500 is legal to purchase for laboratory research purposes. It is not approved for human consumption or medical treatment.
Q: How long does it last after reconstitution?
A: When stored properly in a sterile vial in refrigeration, it is best used within 20 days.
Q: Do you provide documentation?
A: Yes. Each order includes a Certificate of Analysis and lab-grade reference data for your records.
Q: Can TB500 be shipped internationally?
A: We ship to most countries, but it’s your responsibility to comply with local regulations regarding peptides and research chemicals.

Why Choose Us?

✔️ Research-grade quality backed by documentation
✔️ Tamper-proof packaging for product integrity
✔️ Responsive support from industry-experienced staff
✔️ Discreet shipping worldwide
✔️ Bulk pricing available for institutions and labs

Order TB500 (5 mg): Research-Grade Peptide
TB500 continues to be one of the most versatile peptides studied for tissue repair, wound healing, and anti-inflammatory research. With reliable quality, detailed documentation, and professional service, we support your lab’s goals every step of the way.

Combine with BPC157 for added benefits: https://www.uksarms.com/product/bpc-157-body-protection-compound-157/

Continue Your Research

Related compounds: BPC-157 · BPC-157 x TB-500 (Blend) · GLOW Peptide

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